18th International Symposium on Inborn Errors of Immunity

Category:

Description

The universe of primary immunodeficiency diseases is expanding at a fast pace. Currently, there are more than 460 primary immunodeficiency diseases and more than 400 disease causing genes. There have been recent advances in human immunology and in IEI. However, there are challenges in IEI ranging from interpretations of genetic variants to global access to care for IEI and challenges in HSCT and availability of gene therapy for IEI.  Leading experts from all over the globe will be discussing these areas at the 18th International Symposium on IEI to be held on the November 16th-181th, 2023 at VEA Newport Beach, Newport Beach, California.  

We invite you and your colleagues, fellows, and students to attend.  Space is limited to 100 participants. Therefore, early registration is encouraged. Deadline for registration is September 1

Sincerely, 

Jean-Laurent Casanova, Sudhir Gupta, Luigi Notarangelo

Organizers

Abstract

A limited number of abstracts will be selected for oral presentation.  There is no poster presentation. Abstract may be prepared on a single page (8×11) types in single space. It should include title in bold, name of authors (presenting author in bold), and name of the institute. Abstract must be formatted under Rationale, Methods, Results, Conclusions, and no references.  Deadline for abstract submission is October 1, 2023. 

Abstract may be submitted to sgupta@uci.edu

Scientific Program

November 16

7:00 AM Registration
7:00 AM – 9:00 AM Breakfast

Scientific Session I
New Frontiers in Immunology

Co-Chairs: Sudhir Gupta and Luigi Notarangelo

9:00 AM Welcome and Introduction
Sudhir Gupta (USA)
9:10 AM Human Immune Organoids to Model Vaccine Responses and Autoimmunity
Mark Davis (USA)
9:50 AM Dissecting Human Antibody Responses: Useful, Basic and Surprising Findings
Antonio Lanzavecchia (Switzerland)
10:30 AM Coffee Break
10:45 AM T Lymphocyte Differentiation: Lessons Learned From Patients With Inborn Errors of Immunity
Federica Sallusto (Switzerland)
11:25 AM Networks of Ion Channels and Transporters Govern Immune Functions,
Immunodeficiency Diseases, and Therapeutics
K. George Chandy (Singapore)
11:50 AM William E. Paul Memorial Lecture:
The Fundamental Roles of Chromatin Loop Extrusion in Antibody Diversification
Fredrick W Alt (USA)
12:40 PM Lunch

Scientific Session II
Challenges in IEI

Co-Chair: Dan Kastner, Mark Davis

2:10 PM Challenges in the Interpretation of Genetic Variants
Troy Torgerson (USA)
2:40 PM Improving Access to Gene Therapies for Inborn Errors of Immunity
Claire Booth (UK)
3:20 PM Progress and Remaining Challenges in HSCT for SCID
Luigi Notarangelo (USA)
4:00 PM Coffee Break
4:15 PM Global Differences in Access to Care in India
Surjit Singh (India)
4:50 PM Over a Decade Experience on Severe Combined Immunodeficiency Disorders in Algeria
Brahim Belaid (Algeria)
5:30 PM ADJOURN
6:30 PM Invited Speakers Dinner

November 17

Scientific Session III
Recent Advances in IEI (Adaptive Immune Response)

Co-Chairs: Yasmine Belkaid, Troy Torgerson

8:30 AM Thymic Epithelial Cells and Control of Immune Tolerance
Mark Anderson (USA)
9:10 AM Mapping T-cell Developmental Defects Through in Vitro Studies of T-cell and Thymic Epithelial Cell Differentiation
Luigi Notarangelo (USA)
9:50 AM T Follicular Regulatory Cell Aberrations Underlie Diverse IEI Pathologies
Neil Romberg (USA
10:30 AM Coffee Break
10:45 AM Autoantibody Repertoires in Inborn Errors of Immunity
Nils Landegren, (Uppsala)
11:25 AM From Mechanisms of Inborn Errors of Immunity to Precision Medicine in Pediatric Inflammatory Bowel Disease
Elena Hsieh, (USA)
12:05 PM Molecular investigations of Immunological Diseases
Michael Lenardo (USA)
12:45 PM Lunch

Scientific Session IV
Recent Advances in IEI (Innate Immune Response)

Co-Chairs: Michael Lenardo, Jean-Laurent Casanova

2:00 PM More Mechanisms That Lead to Innate Immune Activation: Squeezed Into a Tight Space
Raphaela Goldbach-Mansky (USA)
2:40 PM Towards a Molecular Taxonomy of Autoinflammatory Disease
Daniel Kastner (USA)
3:20 PM Coffee Break
3:35 PM Thomas A Waldmann Memorial Lecture
John O’Shea: Jak-STAT Signaling
4:20 PM Inborn Errors of Type I Interferon Signalling: Protective and Pathogenic Consequences
Chris Duncan, (UK)
5:00 PM ADJOURN
EVENING FREE

NOVEMBER 18

Scientific Session V
Recent Advances in IEI (IEI and Viruses)

Co-Chairs: Nils Landegren, Mark Anderson

8:30 AM Human MxA: The Antiviral Gatekeeper of Zoonotic Influenza Viruses
Martin Schwemmle (Germany)
9:10 AM Inborn Errors of Immunity Affecting Autophagy Pathways in Patients with Viral Infections
Trine Mogensen (Denmark)
9:50 AM Inborn Errors of Immunity Underlying Viral Encephalitis: New Mechanisms of Neuron-intrinsic Antiviral Immunity in Humans
Shen-Ying Zhang (USA)
10:30 AM Coffee Break
10:45 AM Human Genetic and Immunological Determinants of Infectious Diseases
Jean-Laurent Casanova (USA)
11:25 AM A Host Deficiency That Affords Resistance to Viral Replication
Bruno Reversade (Singapore)
12:00 PM Lunch

Scientific Session VI
Free Abstracts Presentations

Co-Chairs: Surjit Singh, Neena Kapoor

1:30 PM Loss of HOXA3 Causes Laryngeal Dysmorphia, Thymic Aplasia and Severe
Combined Immunodeficiency (SCID)
Sarah Dinges (USA)
1:50 PM CMV-Specifically Adaptive Immune Response in U.S. Mannonite Patients With
Hypomorphic RAG1 and RAG2 Mutations Presenting With Clinical Variability
Jolan E Walter (USA)
2:10 PM In Vitro Differentiation of iPSCs to Thymic Epithelial Cells To Model Genetic Thymic Stromal Defects
Kayla Amini
2:30 PM Copy Number Variants in Inborn Errors of Immunity
Amit Rawat (India)
2:50 PM Osteo-immunology of Hyper IgE Syndrome
Biman Saikia
(India)
3:10 PM Vasculitis: New Manifestation of SLC29A3 Related h Syndrome
Amita Aggarwal (India)
3:30 PM Systemic Autoinflammatory Diseases in India: A Decade of Experience
Deepti Suri (India)
3:50 PM Monogenic SLE
Liza Rajasekhar (India)
4:10 PM Gain-of-Function STAT4 Mutations Lead to an Autoinflammatory Syndrome
Responsive to Ruxolitinib
Lori Brodwick (USA)
4:30 PM Deficiency in Astrocyte CCL2 Production Reduces Immune Cell
Infiltration and Host Defense in the CNS During Toxoplasma Gondii Infection
Stephanie B. Orchanian (USA)
4:40 PM ADJOURN
6:00 PM – 10:30 PM GALA BANQUET AND ENTERTAINMENT
Featuring Joe Piscopo (Rivera Ballroom)

Accomodations

For your convenience, a block of rooms has been reserved.  Please use the link below or call to make your  reservation.

https://book.passkey.com/e/50553791

(877) 622-3056 
When calling to make your reservation, please mention the FPID Symposium & Gala in order to receive a discounted rate.

VEA Newport Beach
900 Newport Center Dr
Newport Beach, CA 92660, USA

Event Details

Start date: November 16, 2023

End date: November 18, 2023

Start time: 05:00 p.m. PDT

End time: 04:00 p.m. PDT

Venue: VEA Newport Beach, Newport Beach, California, USA

Related products