The Official Site of The Foundation for Primary Immunodeficiency Diseases (FPID)

There are more than 10 million children and adults with primary immunodeficiency worldwide; more than one half million in the United States, and more than a million in India.

Foundation for Primary Immunodeficiency (FPID) was established in the US to support the education, early diagnosis, genetic counseling, therapy, and research of PID in both India and the United States.

Some Facts About PID

• A large number of patients with PIDs are not even diagnosed.
• Generally, PID is more severe in children than in adults.
• In adults, it may take as long as 25 years from the first symptom to making a diagnosis of PID.
• More than 460 different PIDs and mutations in more than 400 gene mutations associated with or cause of PIDs have been reported.
• Application of GWAS and Exome sequencing has facilitated the identifications of various genes and PIDs.
• Prenatal and neonatal screening for PIDs has also helped in identifying a certain type of PIDs at an early stage so that they could be treated early with a better outcome, often cure.

Though PIDs are 4 times more common than hemophilia, twice common as cystic fibrosis, and almost as common as multiple sclerosis, yet very few people and physicians know about PIDs. Therefore, there is a great need to educate the population in general regarding warning signs of PIDs, and practicing physicians to diagnose and treat these patients to prevent complications and death. In India, there are very few institutions where patients with PIDs are diagnosed or treated; the majority of patients remained undiagnosed and die, contributing in part to India’s high infant mortality rate.